Robert Philibert, Meeshanthini Dogan, Amanda Noel, Shelly Miller, Brianna Krukow, Emma Papworth, Joseph Cowley, Jeffrey D. Long and Donald W. Black, University of Iowa, United States, Behavioral Diagnostics LLC, United States, Cardio Diagnostics, United States, Center for Alcohol and Drug Services, United States Link: Published: Frontiers in Genetics Abstract: The tobacco use...

Philibert, Robert; Dogan, Meeshanthini; Noel, Amanda; Miller, Shelly;  Krukow, Brianna; Cowley, Joseph; Knudsen, April; Beach, Steven; Black, Donald W.  Genome wide and Digital PCR Epigenetic Assessments of Alcohol Consumption. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Link: In Press Abstract: The lack of readily employable biomarkers of alcohol consumption is a...

Philibert RA, Penaluna B, White T, Shires S, Gunter T, Liesveld J, Erwin C, Hollenbeck N, Osborn T. 2014. A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol dependence treatment programs. Epigenetics 9:9:1212-1219. PMID:25147915. Link: https://www.ncbi.nlm.nih.gov/pubmed/25147915 Abstract: Alcoholism has a profound...

Andersen AM, Philibert RA, Gibbons FX, Simons RL, Long J. Accuracy and utility of an epigenetic biomarker for smoking in populations with varying rates of false self-report. Am J Med Genet Part B. 2017; 9999:1–10. Link: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-485X/earlyview Abstract: Better biomarkers to detect smoking are needed given the tremendous public health burden caused by smoking. Current biomarkers...

Philibert R, Hollenbeck N, Andersen E, Osborn T, Gerrard M, Gibbons FX, Wang K. 2015. A quantitative epigenetic approach for the assessment of cigarette consumption. Frontiers in Psychology 6:656. PMID:26082730 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451580/ Abstract: Smoking is the largest preventable cause of morbidity and mortality in the world. Despite the...

Gao X, Jia M, Zhang Y, Breitling LP, Brenner H. 2015. DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. Clinical Epigenetics 7:113. PMC4609112 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609112/ Abstract: Active smoking is a major preventable public health...

Philibert R, Beach SR, Brody GH. 2012. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers.  Epigenetics 7:1331-1338.  PMID:23070629. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499333/ Abstract: Epigenetic modifications to peripheral white blood cell DNA occur in response to a wide variety of exposures. In prior work, we and...

Philibert RA, Sears RA, Powers LS, Nash E, Bair T, Gerke AK, … Monick MM. 2012. Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. Journal of Leukocyte Biology 92(3):621–631. PMID:22427682. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427615/ Abstract: Cigarette smoking is implicated in numerous diseases,...

Monick MM, Beach SRH, Plume J, Sears R, Gerrard M, Brody GH, Philibert RA. 2012. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. American Journal of Medical Genetics 159B(2):141–151. PMID:22232023. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318996/ Abstract: Smoking is associated with a wide variety of adverse health outcomes including cancer,...

Philibert RA, Beach SRH, Lei MK, Brody GH. 2013. Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking. Clinical Epigenetics 5(1):19. PMID:24120260. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819644/ Abstract: Smoking is the largest preventable cause of morbidity and mortality in the United States. In previous...