Robert Philibert, Meeshanthini Dogan, Amanda Noel, Shelly Miller, Brianna Krukow, Emma Papworth, Joseph Cowley, Jeffrey D. Long and Donald W. Black, University of Iowa, United States, Behavioral Diagnostics LLC, United States, Cardio Diagnostics, United States, Center for Alcohol and Drug Services, United States Link: Published: Frontiers in Genetics Abstract: The tobacco use...

Shenker NS, Ueland, PM, Polidoro S, van Veldhoven K, Ricceri F, Brown R, Flanagan JM, Vineis P, Flanagan JM.  2013.  DNA Methylation as a long-term biomarker of exposure to tobacco smoke.  Epidemiology 24:712-716. PMID:23867811. Link: https://www.ncbi.nlm.nih.gov/pubmed/23867811 Abstract: Most biomarkers of exposure tend to have short half-lives. This includes...

Andersen AM, Philibert RA, Gibbons FX, Simons RL, Long J. Accuracy and utility of an epigenetic biomarker for smoking in populations with varying rates of false self-report. Am J Med Genet Part B. 2017; 9999:1–10. Link: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-485X/earlyview Abstract: Better biomarkers to detect smoking are needed given the tremendous public health burden caused by smoking. Current biomarkers...

Philibert R, Hollenbeck N, Andersen E, Osborn T, Gerrard M, Gibbons FX, Wang K. 2015. A quantitative epigenetic approach for the assessment of cigarette consumption. Frontiers in Psychology 6:656. PMID:26082730 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451580/ Abstract: Smoking is the largest preventable cause of morbidity and mortality in the world. Despite the...

Gao X, Jia M, Zhang Y, Breitling LP, Brenner H. 2015. DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. Clinical Epigenetics 7:113. PMC4609112 Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609112/ Abstract: Active smoking is a major preventable public health...

Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM. 2012.  Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking. Human Molecular Genetics....

Philibert R, Beach SR, Brody GH. 2012. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers.  Epigenetics 7:1331-1338.  PMID:23070629. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499333/ Abstract: Epigenetic modifications to peripheral white blood cell DNA occur in response to a wide variety of exposures. In prior work, we and...

Philibert RA, Sears RA, Powers LS, Nash E, Bair T, Gerke AK, … Monick MM. 2012. Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. Journal of Leukocyte Biology 92(3):621–631. PMID:22427682. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427615/ Abstract: Cigarette smoking is implicated in numerous diseases,...

Monick MM, Beach SRH, Plume J, Sears R, Gerrard M, Brody GH, Philibert RA. 2012. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. American Journal of Medical Genetics 159B(2):141–151. PMID:22232023. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318996/ Abstract: Smoking is associated with a wide variety of adverse health outcomes including cancer,...