The scientific principles underlying our patented and patent pending tests have been extensively validated in a dozens of works by a number of research groups including our home group in Iowa. Here is a listing of some of those studies-in particular with respect to those which focus on the sensitivity of methylation at the aryl hydrocarbon receptor repressor locus to smoking.
The term minimalism is also used to describe a trend in design and architecture where in the subject is reduced to its necessary elements. Minimalist design has been highly influenced by Japanese traditional design and archit...
Dogan, M.V., Shields, B., Cutrona, C., Gao, L., Gibbons, F.X., Simons, R., Monick, M., Brody, G., Tan, K. & Philibert, R. (2014) The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African...
Monick MM, Beach SR, Plume JT, Sears R, Gerrard M, Brody GH, Philibert R. (2012). Coordinated Changes in AHRR Methylation in Lymphoblasts and Pulmonary Macrophages from Smokers American Journal of Medical Genetics: Part B Neu...
Philibert R, Sears R, Powers LS, Nash E, Bair T, Gerke A, Hassan I, Thomas C, Gross TJ, Monick MM. 2012b. Coordinated DNA Methylation and Gene Expression Changes in Smoker Alveolar Macrophages: Specific effects on VEGF recept...
Philibert R, Beach SR, Brody GH. 2012. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers. Epigenetics 7:1331-1338. PMID:23070629. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC349933...
Shenker NS, Ueland, PM, Polidoro S, van Veldhoven K, Ricceri F, Brown R, Flanagan JM, Vineis P, Flanagan JM. 2013 DNA Methylation as a Long-term Biomarker of Exposure to Tobacco Smoke. Epidemiology 24:712-716. PMID:2386781...
Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM. (2012) Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutri...
Joubert BR, Håberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, Huang Z, Hoyo C, Midttun Ø, Cupul-Uicab LA, Ueland PM, Wu MC, Nystad W, Bell DA, Peddada SD, London SJ. (2012) 450K Epigenome-Wide Scan Identifies Differential ...
Dogan, M.V., Shields, B., Cutrona, C., Gao, L., Gibbons, F.X., Simons, R., Monick, M., Brody, G., Tan, K. & Philibert, R. (2014) The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African...