The scientific research behind our patented and patent-pending tests have been extensively validated in dozens of works by many research groups, including our home group at the University of Iowa.
Below is a recent list of our publications, as well as selected work from the 50+ publications that have featured our research, technologies, and tests.
The tobacco use disorders are the largest preventable cause of morbidity and mortality in the world. A substantial barrier to the development of better intervention and screening measures is the lack of clinically employable ...
Philibert, Robert; Dogan, Meeshanthini; Noel, Amanda; Miller, Shelly; Krukow, Brianna; Cowley, Joseph; Knudsen, April; Beach, Steven; Black, Donald W. Genome wide and Digital PCR Epigenetic Assessments of Alcohol Consumptio...
Brückmann C, Islam SA, MacIsaac JL, Morin AM, Karle KN, Santo AD, Wüst R, Lang I, Batra A, Kobor MS, Nieratschker V. 2017. DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients underg...
Brückmann C, Santo AD, Karle KN, Batra A, Nieratschker V. 2016. Validation of differential GDAP1 DNA methylation in alcohol dependence and its potential function as a biomarker for disease severity and therapy outcome. Epigen...
Philibert RA, Penaluna B, White T, Shires S, Gunter T, Liesveld J, Erwin C, Hollenbeck N, Osborn T. 2014. A pilot examination of the genome-wide DNA methylation signatures of subjects entering and exiting short-term alcohol d...
Joubert BR, Håberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, Huang Z, Hoyo C, Midttun Ø, Cupul-Uicab LA, Ueland PM, Wu MC, Nystad W, Bell DA, Peddada SD, London SJ. 2012. 450K Epigenome-Wide Scan Identifies Differential D...
Shenker NS, Ueland, PM, Polidoro S, van Veldhoven K, Ricceri F, Brown R, Flanagan JM, Vineis P, Flanagan JM. 2013. DNA Methylation as a long-term biomarker of exposure to tobacco smoke. Epidemiology 24:712-716. PMID:238678...
Andersen AM, Philibert RA, Gibbons FX, Simons RL, Long J. Accuracy and utility of an epigenetic biomarker for smoking in populations with varying rates of false self-report. Am J Med Genet Part B. 2017; 9999:1–10. Link: http:...
Philibert R, Hollenbeck N, Andersen E, Osborn T, Gerrard M, Gibbons FX, Wang K. 2015. A quantitative epigenetic approach for the assessment of cigarette consumption. Frontiers in Psychology 6:656. PMID:26082730 Link: https://...
Gao X, Jia M, Zhang Y, Breitling LP, Brenner H. 2015. DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies. Clinical Epigenetics 7:113. ...
Shenker NS, Polidoro S, van Veldhoven K, Sacerdote C, Ricceri F, Birrell MA, Belvisi MG, Brown R, Vineis P, Flanagan JM. 2012. Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrit...
Philibert R, Beach SR, Brody GH. 2012. Demethylation of the aryl hydrocarbon receptor repressor as a biomarker for nascent smokers. Epigenetics 7:1331-1338. PMID:23070629. Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC...
Philibert RA, Sears RA, Powers LS, Nash E, Bair T, Gerke AK, … Monick MM. 2012. Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. Journal o...
Monick MM, Beach SRH, Plume J, Sears R, Gerrard M, Brody GH, Philibert RA. 2012. Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. American Journal of Medical Genetics 159B(2):141...
Philibert RA, Beach SRH, Lei MK, Brody GH. 2013. Changes in DNA methylation at the aryl hydrocarbon receptor repressor may be a new biomarker for smoking. Clinical Epigenetics 5(1):19. PMID:24120260. Link: https://www.ncbi.nl...