Smoke Signature®

More people are addicted to nicotine than to any other drug. Currently, 15% of all U.S. adults are smokers, according to the U.S. Centers for Disease Control and Prevention (CDC). The CDC also says that nearly 70% of American smokers want to quit – but only 6% succeed on any given year.


This low success rate can frustrate patients, their families, and medical staff – not to mention the wasted resources. Smoke Signature® can help improve transparency between patients and clinicians, allowing all parties to focus on why treatment may not be working instead of trying to determine how many questions to ask or how much information to share.


By understanding how and why specific substances alter an individual’s epigenetic profile, quality of detection and treatment for substance abuse can be customized and improved.


Accurate Cigarette Consumption Results with Smoke Signature®

Now you can measure the exact level of DNA methylation – modification of a gene without changing the sequence – to accurately quantify smoking by a patient over time. Because smoking can strongly modify DNA methylation, leaving a biomarker on the human genome, the impacts of smoking remain in DNA even if cigarettes are no longer being consumed.


More sensitive than other smoking-testing options, Smoke Signature® is specifically designed to test for smoking – not other types of tobacco consumption. This differentiation can help clinicians distinguish between traditional cigarette smoking and the use of e-cigarettes.


The Smoke Signature® test is extremely accurate and can quantify smoking in infrequent and heavy users – and everyone in between. Even if cigarettes haven’t been consumed in several days or weeks, the actions will be documented in the test and can’t be masked by any type of drug or tampering. Attempted interference or contamination of any test sample is easily detected with Smoke Signature.


Behavioral Diagnostics can accept samples, conduct internal testing, and send the Smoke Signature results to you – or you can purchase a test kit and conduct the analysis in the privacy or your own home, research lab, or medical office.

Uses Include:
  • Can be used to establish the smoking status of those seeking life and health insurance.
  • Determination of smoking status in child custody disputes. Custodial parental smoking is the #1 factor affecting the likelihood that the child will subsequently smoke.
  • Prioritization for expensive medical procedures. Smoking is a major risk factor for transplant failure. Our test can help determine priority of potential recipients.


  • Specific for smoking, the use of chewing tobacco, nicotine patches, or “vaping” does not affect the results of our test.
  • Can be used by employers to reduce insurance costs by identifying individuals who can benefit from smoking cessation programs.
  • Since our test uses DNA, by the use of optional genetic barcoding, we can absolutely verify the source of any material used for our test.
  • Completely compatible with standard employee screening procedures.
  • Affordable. Group rates and bundles available. Contact us for more information.